phenobarbital sodium contraindications for Dummies

phenobarbital sodium contraindications for Dummies

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pentobarbital will minimize the extent or effect of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will reduce the level or effect of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lower the extent or effect of finasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.

Contraindicated (one)pentobarbital will lower the extent or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with sturdy CYP3A4 inducers is not encouraged

pentobarbital will reduce the level or effect of atorvastatin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will reduce the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will reduce the level or effect of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid or average CYP3A4 inducers may perhaps enhance fee of diazepam elimination; consequently, efficacy of diazepam can be reduced.

pentobarbital will lower the extent or effect of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will decrease the level or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.

pentobarbital will decrease the extent or effect of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

pentobarbital will minimize the level or effect of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Human facts. Within a 29-12 months epidemiological research of nine,136 patients who have been addressed click here on an anticonvulsant protocol that provided phenobarbital, results indicated a better than normal incidence of hepatic carcinoma. Formerly, Some patients have been dealt with with thorotrast, a drug that is known to supply hepatic carcinomas. So, this research did not supply enough proof that phenobarbital sodium is carcinogenic in humans.

pentobarbital will minimize the level or effect of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Robust or average CYP3A4 inducers may possibly raise level of diazepam elimination; thus, efficacy of diazepam may very well be diminished.

pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can cut down panobinostat concentrations by ~70% and bring on treatment method failure.